English name: Quinidine
Alias:Conchinin; Raclopride; QUINDINE; Chinidin; Cinchonan-9-ol, 6'-methoxy-, (9S)-
Molecular formula: C20H25N2O2
Molecular weight: 325.4242
Appearance and properties: white to pale yellow crystal powder
Density: 0.05 g / 100 mL (20ºC)
Melting point: 168-172 ° C (lit.)
Boiling point: 495.9ºC at 760 mmHg
Flash point: 253.7ºC
Water solubility: 0.05 g / 100 mL (20 ºC)
Stability: Stable. Incompatible with strong oxidizing agents.
Store conditions: Keep containers tightly closed. Store protected from light. Store in a cool, dry area away from incompatible substances.
For cinchu Napa containing alkaloids, quinine isomers. Traits: commonly used for its sulfate, white fine needle crystal; odorless; taste very bitter; case of light gradient color; aqueous solution was dextrorotatory, and significant neutral or alkaline reaction. Soluble in boiling water or ethanol, dissolved in chloroform, slightly soluble in water, almost insoluble in ether.
Items of analysis
a white crystalline powder
Soluble in chloroform,in-soluble in cold water
specific optical rotation
+255 to +265°
loss on drying
Assay(on dried basis)
1, tablets: each 0.2g;
2, quinidine gluconate injection: each 0.5g (10ml).
Oral for atrial premature beats, atrial fibrillation, paroxysmal supraventricular tachycardia, pre-excitation syndrome with supraventricular arrhythmia, premature ventricular contractions, ventricular tachycardia and fibrillation or atrial flutter after electroporation Maintenance treatment. Intramuscular and intravenous no longer needed.
1, oral: the first day, each 0.2g, every 2 hours 1, 5 consecutive times; such as invalid and no significant toxicity, the first 2 days to 0.3g each, the first 3 days each 0.4g, 1 every 2 hours for 5 consecutive times. The daily total should not exceed 2g. After returning to normal heart rhythm, change to maintain the amount of daily 0.2 ~ 0.4g. If even for 3 to 4 days invalid or toxic reaction, should be discontinued.
2, intravenous injection: used when necessary, and must be under ECG observation. Each 0.25g, diluted with 5% glucose solution to 50ml slow intravenous injection. Pediatric 2mg / kg each time.
1, allergy to quinine may also be allergic to this product.
2, in view of the human body is less, and closely related to the drug - quinine can produce fetal central nervous system and limb deformities, neonatal ototoxicity and oxytocin, pregnant women should weigh the pros and cons. This product can be excreted through the milk, with breast milk into children, although the amount of infants received much lower than the amount of treatment, but due to immature liver development, poor metabolism of drugs, may lead to drug accumulation. Elderly due to decreased ability to clear, with appropriate reduction.
3, the following should be disabled: digitalis poisoning; II to III degree atrioventricular block (unless there is a pacemaker); sick sinus syndrome; cardiogenic shock; severe liver or renal dysfunction; Ning or its derivatives are allergic; thrombocytopenia (including those with previous history).
4, the following conditions should be used in town; allergic patients; liver or renal dysfunction; untreated heart failure; I degree atrioventricular block; extreme bradycardia; hypotension (arrhythmia caused by not included); low Potassium. Severe myocardial damage and pregnant women hanged, quinidine can pass through the placenta, affecting fetal cardiac function.
|Synonyms||Conchinin; Raclopride; QUINDINE|
|Usage||Oral for atrial premature beats, atrial fibrillation, paroxysmal supraventricular tachycardia, pre-excitation syndrome with supraventricular arrhythmia, premature ventricular contractions, ventricular tachycardia and fibrillation or atrial flutter after electroporation Maintenance treatment. Intramuscular and intravenous no longer needed|
|Packing||foil bag or tin.|
|Storage||Keep it under seal in cool and dark place|
|Certificate||ISO9001, KOSHER, REACH|
|Supply ability||Mass stock|
|Delivery time||safe &timely, around 1-3 days after payment|
|Shipping methods||: EMS,Fedex.TNT,DHL and so on|
|Payment term:||Bank transfer, Western Union, Money Gram, BankWire, T/T|
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