Pharmaceutical Raw Material White Powder Antifungal Medications Ketoconazole CAS: 65277-42-1Basic Info
|Melting point||146 ºC|
|Appearance||white or almost white crystalline powder|
a.Systemic fungal infections,such as systemic candidiasis,Candida,under spherical spore bacteria disease,histoplasma fungus disease,ball,Bud spore bacteria disease bacteria.
b.By skin fungi and (or) yeast caused of skin,and hair and refers to (toe) of infection (skin fungi disease,and methyl Tinea,and beads bacteria sex methyl week inflammatory,and spotted Tinea,and scalp bran rash Tinea sex hair follicles inflammatory and the chronic skin mucosa beads bacteria disease),dang local treatment invalid or due to infection parts,and area and the depth,factors cannot medication Shi,available the products treatment.
c.Local treatment of chronic,recurrent vaginal candidiasis.
d.For prophylaxis because of reduced immune function (genetic and caused by disease or drugs) and prone to fungal infections in patients.Application
This product is an imidazole antifungal drug.For skin fungi, yeasts (Candida, pityrosporum bacteria genus,ball intends to Saccharomyces,Cryptococcus),duplex fungi or Eumycetes bacteriostatic and bactericidal action;apart from the entomophthorales,the product of the Aspergillus,Shen sporotrichum,some dark Spore,Mucor are lower.The main mechanism for highly selective disturbance of activity of fungal cytochrome P-450,thus inhibiting cell membrane ergosterol biosynthesis in fungi.Specification
|Characters||white or almost white powder||Qualified|
|Identification||Meets the requirements||Qualified|
|Melting range||148°C ~ 152°C||148.0~ 150.0°C|
|Appearance of solution||Meets the requirements||Qualified|
|Organic volatile impurities||Meets USP30||Qualified|
|Specific rotation||-1° ~ +1°(USP30)||0°|
| ||-0.10° ~ +0.10°(EP5.0,BP2005)|| |
|Chromatographic purity||Meets the requirements||Qualified|
|Loss on drying||≤0.5%||0.001|
|Residue on ignition||≤0.1%||0.0005|
|Assay||98.0% ~ 102.0%(USP30)||0.9969|
| ||99.0%~101.0%(EP5.0,BP2005)|| |
|CONCLUSION:||This is certify that the product complies to the standards of USP29,EP5.0,BP2005|
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