Raw Pharmaceutical powder Lenvatinib mesylate effect on cancer Our advantages:
Product name: Lenvatinib mesylate
Alias: Lenvatinib mesylate [USAN]; 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide mesylate; 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7- Methoxy-6-quinolinecarboxamide methanesulfonate; 4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7-methoxyquinoline-6-carboxamide, methanesulfonic acid; Lenvatinib mesilate (JAN);
CAS number: 857890-39-2
Molecular weight: 522.995900
Exact Mass: 522.09800
DTC is the most common form of thyroid cancer. It is a cancerous growth of the thyroid. The thyroid is located in the neck and it helps regulate the body's metabolism. The National Cancer Institute predicts that 62.98 million people will be diagnosed with thyroid cancer in 2014 and 1,890 will die of the disease. Lenvima is a kinase inhibitor that acts by blocking certain proteins to help cancer cells grow and differentiate.
"The development of new therapeutic drugs to help people with refractory diseases is a matter of great importance to the FDA," said Pazdur, MD, director of the Office of Metabolism and Oncology Products, FDA Center for Drug Evaluation and Research. "Today's approval provides patients and health care professionals with a new treatment that can help delay the deterioration of DTCs."
Lenvima is completed under the FDA's priority review process. The review of the priority review drug provides an accelerated review. If the drug is approved, it will provide safety and efficacy in the treatment of serious diseases. Obvious improvement.
The drug is also eligible for orphan drug because it aims to treat a rare disease. Lenvima's approval time is approximately 2 months earlier than its target drug applicant's target payment date of April 14, 2015, and April 14, 2015 is the last time the FDA plans to complete the drug review.
The efficacy of Lenvima was based on 392 subjects with invasive, radioiodine-treated DTC who were randomized to Lenvima or placebo. The results of the study showed that the median progression-free survival of subjects treated with Lenvima was 18.3 months, compared with 3.6 months for those treated with placebo.
In addition, 65% of Lenvima-treated subjects had tumor shrinkage compared to only 2% of subjects receiving placebo. Most subjects randomized to placebo were treated with Lenvima after the disease had worsened.
Lenvima Most Common Side Effects
High blood pressure, fatigue, diarrhea, joint muscle pain (joint pain/muscle pain), decreased appetite, vomiting, excessive urine proteinuria (proteinuria), palm swelling and pain, hand and/or sole floor (hand-foot syndrome) , abdominal pain and pronunciation change (voice disorder).
Lenvima can cause serious side effects including heart failure, thrombosis (arterial thromboembolic events), liver damage (liver toxicity), kidney damage (renal failure and injury), perforation of the gastrointestinal tract, or abnormal connection between the stomach or intestines, electrocardiographic activity Changes (prolonged QT interval), hypocalcemia, concomitant headaches, seizures and visual changes (reversible leukoencephalopathy syndrome), severe bleeding (major bleeding), risk of unborn babies if treated during pregnancy, and thyrotropia Hormone production appears to be inhibited. Lenvima is marketed by Eisai, located in New Jersey.
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|Minimum order quantity||10g|
|Packaging Details||1kg/aluminium foil bag or as required|
|Delivery time||Within 24 hours after receiving the payment|
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